Ur-144 or km-x1 or mn 001

Tēma sadaļā 'Cannabinoids', bija izveidotā Charles Darwin, 2/5/14.

  1. TS
    Charles Darwin

    Charles Darwin Guest

    UR-144(TMCP-018,KM-X1,MN-001,YX-17)

    is a drug invented by
    , that acts as a selective
    of the peripheral
    , but with much lower
    for the psychoactive
    receptor.

    Pharmacology

    UR-144 has high affinity for the CB2receptor with a Kiof 1.8 nM but 83x lower affinity for the CB1receptor with a Kiof 150 nM. Although a later study found its CB1affinity to be much higher than previously expected, with a Kiof 28.9nM and a EC50of 1295nM. ChemiCally it is closely related to other 2,2,3,3-tetramethylcyclopropyl synthetic cannabinoids like
    and
    but with a different substitution on the 1-position of the indole core, in these compounds its 1-pentyl group is replaced with alkylheterocycles like 1-(2-morpholinoethyl) and 1-(tetrahydropyran-4-ylmethyl).

    History of use

    UR-144 has been detected as an ingredient of
    smoking blends in New Zealand, and subsequently banned from sale as a
    on 6 April 2012.It has also been encountered in smoking blends and subsequently banned in Russia.

    The chemical UR-144 has also been banned in the UK in 2013 along with
    and
    . This is due to two people in Glasgow being admitted to hospital after taking a legal high with the chemicals in. Another person was admitted to Brighton hospital after over dosing on the drug
     
    • Мне нравится Мне нравится x 1
    Charles Darwin, 2/5/14
    #1